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Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied up to 1,359,002 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.00661 higher (95% confidence interval 0.0044-0.0088); p = 2 × 10−9.
How common The G allele had a frequency of about 61% in the people studied.
Where it sits Chromosome 2, band 2p12 — inside CTNNA2.
What each result means
A/ANo copy of the version the research linked to Smoking initiation (ever regular vs never regular) (MTAG). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Smoking initiation (ever regular vs never regular) (MTAG). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Smoking initiation (ever regular vs never regular) (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2019 · PMID 30643251 · open access
Questions about rs1434206
What is rs1434206?
rs1434206 is a single position in the genome, in or near the CTNNA2 gene. Published research associates it with smoking initiation (ever regular vs never regular) (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1434206 linked to?
On MyGeneLog this position is linked to Smoking Behaviour and Nicotine Dependence. The research behind each link, and its sources, are set out on that condition page.
Does having rs1434206 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1434206 come from?
GWAS Catalog, Nature genetics 2019, PMID:30643251. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Smoking initiation (ever regular vs never regular) (MTAG) (rs1434206). MyGeneLog™. https://www.mygenelog.com/variants/rs1434206