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Retinal arteriolar tortuosity

near PROCR · rs143373163

What the study found

Who was studied 52,798 European ancestry individuals; replicated in 4,987 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.033 higher (95% confidence interval 0.023-0.043); p = 4 × 10−11.

How common The G allele had a frequency of about 91% in the people studied.

Where it sits Chromosome 20, band 20q11.22 — between genes, 7.5 kb from PROCR.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Retinal arteriolar tortuosity compared to the general population.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Retinal arteriolar tortuosity.
T/T Published research associates this genotype with typical/baseline likelihood of Retinal arteriolar tortuosity — no copies of the reported risk allele.
Source

Questions about rs143373163

What is rs143373163?

rs143373163 is a single position in the genome, in or near the near PROCR gene. Published research associates it with retinal arteriolar tortuosity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs143373163 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs143373163 come from?

GWAS Catalog, PLoS genetics 2023, PMID:36757925. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Retinal arteriolar tortuosity (rs143373163). MyGeneLog™. https://www.mygenelog.com/variants/rs143373163

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