0 2111333217Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI3Microsoft · Copilot3Amazon3Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others7Total21Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 147,997 European ancestry cases, 575,269 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0315 higher (95% confidence interval 0.022-0.041); p = 6 × 10−12.
How common The A allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 10, band 10q22.1 — a missense change in CDH23.
What ClinVar records
ClassificationConflicting classifications of pathogenicity for Usher syndrome type 1D, Autosomal recessive nonsyndromic hearing loss 12, Nonsyndromic genetic hearing loss, Usher syndrome type 1, Retinal dystrophy; criteria provided, conflicting classifications (1 of 4 stars, 17 submitters), last evaluated 2026-06-01.
ClinVar record 44114NM_022124.6(CDH23):c.1096G>A (p.Ala366Thr)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to Age-related hearing impairment. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Age-related hearing impairment. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Age-related hearing impairment. This is the starting point the study compared everyone against.
American journal of human genetics · 2022 · PMID 35580588 · open access
Questions about rs143282422
What is rs143282422?
rs143282422 is a single position in the genome, in or near the CDH23 gene. Published research associates it with age-related hearing impairment. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs143282422 linked to?
On MyGeneLog this position is linked to Age-Related Hearing Loss. The research behind each link, and its sources, are set out on that condition page.
Does having rs143282422 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs143282422 come from?
GWAS Catalog, American journal of human genetics 2022, PMID:35580588. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 2111333217Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI3Microsoft · Copilot3Amazon3Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others7Total21Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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