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Neuroticism

LINC01876 · rs1431965

Where this position leads

Condition: Neuroticism

rs1431965 Condition: Neuroticism Neuroticism Condition rs1431965 rs1431965 LINC01876

What the study found

Who was studied 523,783 European ancestry individuals; replicated in 59,206 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0135 lower (95% confidence interval 0.0097-0.0172); p = 2 × 10−12.

How common The C allele had a frequency of about 21% in the people studied.

Where it sits Chromosome 2, band 2q24.1 — inside LINC01876.

What each result means

C/C Two copies of the version the research linked to Neuroticism. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Neuroticism. That is a smaller link than two copies.
T/T No copy of the version the research linked to Neuroticism. This is the starting point the study compared everyone against.
Source

Questions about rs1431965

What is rs1431965?

rs1431965 is a single position in the genome, in or near the LINC01876 gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1431965 linked to?

On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.

Does having rs1431965 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1431965 come from?

GWAS Catalog, Nature genetics 2019, PMID:30643256. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Neuroticism (rs1431965). MyGeneLog™. https://www.mygenelog.com/variants/rs1431965

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