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Who was studied 129,080 European ancestry cases, 473,524 European ancestry controls; replicated in 462,753 cases, 1,127,474 controls.
The effect
Each copy of the A allele shifted the measure 0.032 lower; p = 3 × 10−11.
How common The A allele had a frequency of about 57% in the people studied.
Where it sits Chromosome 18, band 18q21.2 — in an intron of DCC.
What each result means
A/ATwo copies of the version the research linked to Gastroesophageal reflux disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Gastroesophageal reflux disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Gastroesophageal reflux disease. This is the starting point the study compared everyone against.
rs1431196 is a single position in the genome, in or near the DCC gene. Published research associates it with gastroesophageal reflux disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1431196 linked to?
On MyGeneLog this position is linked to Gastroesophageal Reflux Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs1431196 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1431196 come from?
GWAS Catalog, Gut 2022, PMID:34187846. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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