Sensitive

Depression

DCC · rs1431181

Where this position leads

Condition: Endometriosis and Depression: Shared Genetics

rs1431181 Condition: Endometriosis and Depression: Shared Genetics Endometriosis and Depression: Share… Condition rs1431181 rs1431181 DCC

What the study found

Who was studied 688,809 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 6.96 z score higher; p = 3 × 10−12.

Where it sits Chromosome 18, band 18q21.2 — in an intron of DCC.

What each result means

A/A Two copies of the version the research linked to Depression. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Depression. That is a smaller link than two copies.
G/G No copy of the version the research linked to Depression. This is the starting point the study compared everyone against.
Source

Questions about rs1431181

What is rs1431181?

rs1431181 is a single position in the genome, in or near the DCC gene. Published research associates it with depression. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1431181 linked to?

On MyGeneLog this position is linked to Endometriosis and Depression: Shared Genetics. The research behind each link, and its sources, are set out on that condition page.

Does having rs1431181 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1431181 come from?

GWAS Catalog, Nature genetics 2018, PMID:29942085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Depression (rs1431181). MyGeneLog™. https://www.mygenelog.com/variants/rs1431181

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