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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 342,990 European ancestry individuals, 150,068 East Asian ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0678 higher (95% confidence interval 0.048-0.088); p = 4 × 10−11.
Where it sits Chromosome 1, band 1p22.1 — in an intron of BTBD8.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Aspartate aminotransferase levels compared to the general population.
A/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Aspartate aminotransferase levels.
T/TPublished research associates this genotype with typical/baseline likelihood of Aspartate aminotransferase levels — no copies of the reported risk allele.
rs143105156 is a single position in the genome, in or near the BTBD8 gene. Published research associates it with aspartate aminotransferase levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs143105156 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs143105156 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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