0 181122210Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others10Total18Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 56,184 European ancestry cases, 90,919 European ancestry controls.
The effect
Each copy of the C allele carried 1.44 times the odds of Alzheimer's disease (95% confidence interval 1.28-1.61); p = 1 × 10−9.
How common The C allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 2, band 2q12.2 — in an intron of NCK2.
What each result means
C/CTwo copies of the version the research linked to Alzheimer's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Alzheimer's disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Alzheimer's disease. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 42237039 · open access
Questions about rs143080277
What is rs143080277?
rs143080277 is a single position in the genome, in or near the NCK2 gene. Published research associates it with alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs143080277 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs143080277 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs143080277 come from?
GWAS Catalog, Nature genetics 2026, PMID:42237039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 181122210Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others10Total18Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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