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Who was studied 12,074 European, African, Admixed American, Asian or unknown ancestry cases, 15,833 European, African, Admixed American, Asian or unknown ancestry controls.
The effect
The reported allele is G; the catalogue records no effect size
; p = 2 × 10−8.
Where it sits Chromosome 18, band 18q21.1 — in an intron of DYM.
What each result means
A/ANo copy of the version the research linked to Alzheimer's disease. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Alzheimer's disease. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Alzheimer's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025 · PMID 39998322 · open access
Questions about rs142978359
What is rs142978359?
rs142978359 is a single position in the genome, in or near the DYM gene. Published research associates it with alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs142978359 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs142978359 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs142978359 come from?
GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2025, PMID:39998322. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1512318Reads by AI crawlersClaude0ChatGPT0Google · Gemini1Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others8Total15Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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