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Total testosterone levels

near PPIHP2 · rs142779773

What the study found

Who was studied 95,184 European ancestry males, 27,521 African American or Afro-Caribbean males, 13,443 Admixed American ancestry males, 1,836 East Asian ancestry males.

The effect Each copy of the C allele shifted the measure 1.3 lower (95% confidence interval 0.86-1.74); p = 8 × 10−9.

Where it sits Chromosome X, band Xq23 — between genes, 20.5 kb from PPIHP2.

What each result means

C/C Two copies of the version the research linked to Total testosterone levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Total testosterone levels. That is a smaller link than two copies.
T/T No copy of the version the research linked to Total testosterone levels. This is the starting point the study compared everyone against.
Source

Questions about rs142779773

What is rs142779773?

rs142779773 is a single position in the genome, in or near the near PPIHP2 gene. Published research associates it with total testosterone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs142779773 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs142779773 come from?

GWAS Catalog, Nature communications 2025, PMID:40316537. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Total testosterone levels (rs142779773). MyGeneLog™. https://www.mygenelog.com/variants/rs142779773

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