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Its strongest genetic-study result is p = 10−11, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 450 African American or Afro-Caribbean cases, 121,343 African American or Afro-Caribbean controls, 2,370 European ancestry cases, 448,487 European ancestry controls, 283 Hispanic or Latin American cases, 59,586 Hispanic or Latin American controls.
The effect
Each copy of the A allele shifted the measure 2.73 lower (95% confidence interval 2.7-2.77); p = 3 × 10−11.
How common The A allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 8, band 8q24.13 — in an intron of LINC00861.
What each result means
A/ATwo copies of the version the research linked to Thyroid cancer (PheCode 193). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Thyroid cancer (PheCode 193). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Thyroid cancer (PheCode 193). This is the starting point the study compared everyone against.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs142700723
What is rs142700723?
rs142700723 is a single position in the genome, in or near the LINC00861 gene. Published research associates it with thyroid cancer (phecode 193). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs142700723 linked to?
On MyGeneLog this position is linked to Thyroid Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs142700723 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs142700723 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Thyroid cancer (PheCode 193) (rs142700723). MyGeneLog™. https://www.mygenelog.com/variants/rs142700723