TG · rs142698837
Where this position leads
Condition: Thyroid Cancer
Strength of the evidence
Its strongest genetic-study result is p = 10−47, with 7 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 14,764 European ancestry cases, 2,091,602 European ancestry controls.
The effect Each copy of the A allele shifted the measure 1.11 higher (95% confidence interval 0.87-1.34); p = 3 × 10−20.
How common The A allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 8, band 8q24.22 — a missense change in TG.
What ClinVar records
Classification
Conflicting classifications of pathogenicity for Iodotyrosyl coupling defect, Autoimmune thyroid disease, susceptibility to, 3, TG-related disorder, Congenital hypothyroidism; criteria provided, conflicting classifications (1 of 4 stars, 20 submitters), last evaluated 2026-04-27.
ClinVar record 436996 NM_003235.5(TG):c.229G>A (p.Gly77Ser)
Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs142698837 is a single position in the genome, in or near the TG gene. Published research associates it with thyroid cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Thyroid Cancer. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, GWAS Catalog n.d., PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Thyroid cancer (rs142698837). MyGeneLog™. https://www.mygenelog.com/variants/rs142698837