0 1023122Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity2Meta AI3Microsoft · Copilot1Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total10Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 243 African American or Afro-Caribbean cases, 120,331 African American or Afro-Caribbean controls, 642 European ancestry cases, 446,916 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 3.03 lower (95% confidence interval 3-3.05); p = 1 × 10−12.
How common The C allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 19, band 19p13.3 — a missense change in ABCA7.
What ClinVar records
ClassificationLikely benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2021-10-06.
ClinVar record 2347903NM_019112.4(ABCA7):c.3542C>T (p.Pro1181Leu)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CTwo copies of the version the research linked to Acute laryngitis and tracheitis (PheCode 465.4). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Acute laryngitis and tracheitis (PheCode 465.4). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Acute laryngitis and tracheitis (PheCode 465.4). This is the starting point the study compared everyone against.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs142601420
What is rs142601420?
rs142601420 is a single position in the genome, in or near the ABCA7 gene. Published research associates it with acute laryngitis and tracheitis (phecode 465.4). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs142601420 linked to?
On MyGeneLog this position is linked to Acute Laryngitis and Tracheitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs142601420 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs142601420 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1023122Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity2Meta AI3Microsoft · Copilot1Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total10Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Acute laryngitis and tracheitis (PheCode 465.4) (rs142601420). MyGeneLog™. https://www.mygenelog.com/variants/rs142601420