Standard
Osteoprotegerin levels
COLEC10 · rs1425053
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Osteoprotegerin levels compared to the general population.
A/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Osteoprotegerin levels.
T/T
Published research associates this genotype with typical/baseline likelihood of Osteoprotegerin levels — no copies of the reported risk allele.
Source
Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels
Kwan JS,
Hsu YH,
Cheung CL,
Dupuis J,
Saint-Pierre A,
Eriksson J,
Handelman SK,
Aragaki A,
Karasik D,
Pramstaller PP,
Kooperberg C,
Lacroix AZ
and 13 more — show all
Larson MG,
Lau KS,
Lorentzon M,
Pichler I,
Sham PC,
Taliun D,
Vandenput L,
Kiel DP,
Hicks AA,
Jackson RD,
Ohlsson C,
Benjamin EJ,
Kung AW
Human molecular genetics · 2014 · PMID 25080503
Questions about rs1425053
What is rs1425053?
rs1425053 is a single position in the genome, in or near the COLEC10 gene. Published research associates it with osteoprotegerin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1425053 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1425053 come from?
GWAS Catalog, Hum Mol Genet 2014, PMID:25080503. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants