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Alanine aminotransferase levels

near HP · rs1424241

What the study found

Who was studied 344,136 European ancestry individuals, 150,545 East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0226 higher (95% confidence interval 0.017-0.028); p = 3 × 10−17.

Where it sits Chromosome 16, band 16q22.2 — between genes, 9.5 kb from HP.

What each result means

A/A Two copies of the version the research linked to Alanine aminotransferase levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Alanine aminotransferase levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Alanine aminotransferase levels. This is the starting point the study compared everyone against.
Source

Questions about rs1424241

What is rs1424241?

rs1424241 is a single position in the genome, in or near the near HP gene. Published research associates it with alanine aminotransferase levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1424241 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1424241 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Alanine aminotransferase levels (rs1424241). MyGeneLog™. https://www.mygenelog.com/variants/rs1424241

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