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Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.
The effect
Each copy of the G allele shifted the measure 0.02 mmol/L lower (95% confidence interval 0.02-0.02); p = 2 × 10−10.
Where it sits Chromosome 19, band 19p13.2 — in an intron of INSR.
What each result means
A/ANo copy of the version the research linked to Triglycerides in LDL. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Triglycerides in LDL. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Triglycerides in LDL. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 41044249 · open access
Questions about rs142407017
What is rs142407017?
rs142407017 is a single position in the genome, in or near the INSR gene. Published research associates it with triglycerides in ldl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs142407017 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Does having rs142407017 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs142407017 come from?
GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Triglycerides in LDL (rs142407017). MyGeneLog™. https://www.mygenelog.com/variants/rs142407017