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Who was studied 13,708 European ancestry cases, 95,282 European ancestry controls; replicated in 5,353 European ancestry cases, 5,551 European ancestry controls.
The effect
Each copy of the A allele carried 1.10 times the odds of Parkinson's disease (95% confidence interval 1.08-1.13); p = 2 × 10−12.
How common The A allele had a frequency of about 38% in the people studied.
Where it sits Chromosome 16, band 16p11.2 — a synonymous change in BCKDK.
What ClinVar records
ClassificationBenign for Branched-chain keto acid dehydrogenase kinase deficiency; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 6 submitters), last evaluated 2026-02-03.
ClinVar record 128521NM_005881.4(BCKDK):c.615G>A (p.Thr205=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to Parkinson's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Parkinson's disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Parkinson's disease. This is the starting point the study compared everyone against.
Nature genetics · 2014 · PMID 25064009 · open access
Questions about rs14235
What is rs14235?
rs14235 is a single position in the genome, in or near the BCKDK gene. Published research associates it with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs14235 linked to?
On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs14235 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs14235 come from?
GWAS Catalog, Nat Genet 2014, PMID:25064009. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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