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White matter microstructure (mean diusivities) Fornix (PC4)

LPAR4 · rs142344396

What the study found

Who was studied 37,772 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 6.27 z score higher; p = 4 × 10−10.

Where it sits Chromosome X, band Xq21.1 — at a splice region of LPAR4.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of White matter microstructure (mean diusivities) Fornix (PC4) compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with White matter microstructure (mean diusivities) Fornix (PC4).
G/G Published research associates this genotype with typical/baseline likelihood of White matter microstructure (mean diusivities) Fornix (PC4) — no copies of the reported risk allele.
Source

Questions about rs142344396

What is rs142344396?

rs142344396 is a single position in the genome, in or near the LPAR4 gene. Published research associates it with white matter microstructure (mean diusivities) fornix (pc4). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs142344396 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs142344396 come from?

GWAS Catalog, Science advances 2025, PMID:39854466. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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White matter microstructure (mean diusivities) Fornix (PC4) (rs142344396). MyGeneLog™. https://www.mygenelog.com/variants/rs142344396

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