Venous thromboembolism adjusted for sickle cell variant rs77121243-T
LOC100130298 · rs142143628
6 3812712322Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity2Meta AI7Microsoft · Copilot1Amazon2Apple3Others22Total38Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 393 African American cases, 4,941 African American controls..
The effect
Each copy of the T allele carried 4.97 times the odds of Venous thromboembolism adjusted for sickle cell variant rs77121243-T (95% confidence interval 2.801-8.83); p = 4 × 10−8.
How common The T allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 8, band 8q12.2 — in an intron of CLVS1.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Venous thromboembolism adjusted for sickle cell variant rs77121243-T — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Venous thromboembolism adjusted for sickle cell variant rs77121243-T.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Venous thromboembolism adjusted for sickle cell variant rs77121243-T compared to the general population.
rs142143628 is a single position in the genome, in or near the LOC100130298 gene. Published research associates it with venous thromboembolism adjusted for sickle cell variant rs77121243-t. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs142143628 linked to?
On MyGeneLog this position is linked to Venous Thromboembolism. The research behind each link, and its sources, are set out on that condition page.
Does having rs142143628 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs142143628 come from?
GWAS Catalog, Thromb Haemost 2017, PMID:28203683. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
6 3812712322Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity2Meta AI7Microsoft · Copilot1Amazon2Apple3Others22Total38Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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