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Neutrophil-to-lymphocyte ratio

near PPIAP54 · rs141951483

What the study found

Who was studied 234,502 European ancestry individuals; replicated in 100,442 European ancestry individuals.

The effect The reported allele is C; the catalogue records no effect size ; p = 1 × 10−16.

How common The C allele had a frequency of about 91% in the people studied.

Where it sits Chromosome 17, band 17q21.2 — between genes, 1.1 kb from PPIAP54.

What each result means

C/C Two copies of the version the research linked to Neutrophil-to-lymphocyte ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Neutrophil-to-lymphocyte ratio. That is a smaller link than two copies.
T/T No copy of the version the research linked to Neutrophil-to-lymphocyte ratio. This is the starting point the study compared everyone against.
Source

Questions about rs141951483

What is rs141951483?

rs141951483 is a single position in the genome, in or near the near PPIAP54 gene. Published research associates it with neutrophil-to-lymphocyte ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs141951483 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs141951483 come from?

GWAS Catalog, American journal of human genetics 2021, PMID:34469753. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Neutrophil-to-lymphocyte ratio (rs141951483). MyGeneLog™. https://www.mygenelog.com/variants/rs141951483

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