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Dynorphin A (1-17) levels

PDYN · rs1418037

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2,721 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.196 higher (95% confidence interval 0.15-0.25); p = 4 × 10−15.

How common The C allele had a frequency of about 36% in the people studied.

Where it sits Chromosome 20, band 20p13 — in an intron of PDYN.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Dynorphin A (1-17) levels compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Dynorphin A (1-17) levels.
T/T Published research associates this genotype with typical/baseline likelihood of Dynorphin A (1-17) levels — no copies of the reported risk allele.
Source
Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease
Western D, Timsina J, Wang L, Wang C, Yang C, Phillips B, Wang Y, Liu M, Ali M, Beric A, Gorijala P, Kohlfeld P
and 28 more — show all
Budde J, Levey AI, Morris JC, Perrin RJ, Ruiz A, Marquié M, Boada M, de Rojas I, Rutledge J, Oh H, Wilson EN, Le Guen Y, Reus LM, Tijms B, Visser PJ, van der Lee SJ, Pijnenburg YAL, Teunissen CE, Del Campo Milan M, Alvarez I, Aguilar M, Greicius MD, Pastor P, Pulford DJ, Ibanez L, Wyss-Coray T, Sung YJ, Cruchaga C
Dominantly Inherited Alzheimer Network (DIAN) · Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Nature genetics · 2024 · PMID 39528825

Questions about rs1418037

What is rs1418037?

rs1418037 is a single position in the genome, in or near the PDYN gene. Published research associates it with dynorphin a (1-17) levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1418037 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1418037 come from?

GWAS Catalog, Nature genetics 2024, PMID:39528825. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Dynorphin A (1-17) levels (rs1418037). MyGeneLog™. https://www.mygenelog.com/variants/rs1418037

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