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Cholesterol efflux capacity (BHK stimulated assay)

APOE/C1/C2/C4 · rs141622900

Where this position leads

Drug: Lecanemab and other anti-amyloid antibodies

What the study found

Who was studied 3,487 French-Canadian ancestry cases, 1,806 French-Canadian ancestry controls.

The effect Each copy of the G allele shifted the measure 0.283 lower (95% confidence interval 0.20-0.37); p = 1 × 10⁻¹¹.

How common The G allele had a frequency of about 94% in the people studied.

Where it sits Chromosome 19, band 19q13.32 — between genes, 2.4 kb from APOC1P1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Cholesterol efflux capacity (BHK stimulated assay) — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cholesterol efflux capacity (BHK stimulated assay).

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cholesterol efflux capacity (BHK stimulated assay) compared to the general population.

Source

Variants at the APOE /C1/C2/C4 Locus Modulate Cholesterol Efflux Capacity Independently of High-Density Lipoprotein Cholesterol

Low-Kam C, Rhainds D, Lo KS, Barhdadi A, Boulé M, Alem S, Pedneault-Gagnon V, Rhéaume E, Dubé MP, Busseuil D, Hegele RA, Lettre G

and 1 more — show all

Tardif JC

Journal of the American Heart Association · 2018 · PMID 30369316 · open access

Questions about rs141622900

What is rs141622900?

rs141622900 is a single position in the genome, in or near the APOE/C1/C2/C4 gene. Published research associates it with cholesterol efflux capacity (bhk stimulated assay). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs141622900 affect how medicines work?

APOE/C1/C2/C4 carries pharmacogenomic findings for Lecanemab and other anti-amyloid antibodies. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs141622900 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs141622900 come from?

GWAS Catalog, J Am Heart Assoc 2018, PMID:30369316. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cholesterol efflux capacity (BHK stimulated assay) (rs141622900). MyGeneLog™. https://www.mygenelog.com/variants/rs141622900

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