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Who was studied at least 170,756 European ancestry cases, at least 329,443 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.0427 higher (95% confidence interval 0.028-0.058); p = 3 × 10−8.
How common The T allele had a frequency of about 92% in the people studied.
Where it sits Chromosome 13, band 13q32.1 — in an intron of HS6ST3.
What each result means
C/CNo copy of the version the research linked to Major depressive disorder (MTAG). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Major depressive disorder (MTAG). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Major depressive disorder (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Translational psychiatry · 2021 · PMID 33479212 · open access
Questions about rs1414622
What is rs1414622?
rs1414622 is a single position in the genome, in or near the HS6ST3 gene. Published research associates it with major depressive disorder (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1414622 linked to?
On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs1414622 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1414622 come from?
GWAS Catalog, Translational psychiatry 2021, PMID:33479212. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Major depressive disorder (MTAG) (rs1414622). MyGeneLog™. https://www.mygenelog.com/variants/rs1414622