Sensitive

Bladder cancer in ever smokers

near MTAP · rs1414253

Where this position leads

What the study found

Who was studied 9,251 European ancestry cases, 57,124 European ancestry controls.

The effect Each copy of the A allele carried 1.14 times the odds of Bladder cancer in ever smokers (95% confidence interval 1.09-1.19); p = 1 × 10⁻⁸.

Where it sits Chromosome 9, band 9p21.3 — between genes, 47 kb from MTAP.

What each result means

A/A Two copies of the version the research linked to Bladder cancer in ever smokers. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Bladder cancer in ever smokers. That is a smaller link than two copies.

G/G No copy of the version the research linked to Bladder cancer in ever smokers. This is the starting point the study compared everyone against.

Source

Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights

Koutros S, Kiemeney LA, Pal Choudhury P, Milne RL, Lopez de Maturana E, Ye Y, Joseph V, Florez-Vargas O, Dyrskjøt L, Figueroa J, Dutta D, Giles GG

and 88 more — show all

Hildebrandt MAT, Offit K, Kogevinas M, Weiderpass E, McCullough ML, Freedman ND, Albanes D, Kooperberg C, Cortessis VK, Karagas MR, Johnson A, Schwenn MR, Baris D, Furberg H, Bajorin DF, Cussenot O, Cancel-Tassin G, Benhamou S, Kraft P, Porru S, Carta A, Bishop T, Southey MC, Matullo G, Fletcher T, Kumar R, Taylor JA, Lamy P, Prip F, Kalisz M, Weinstein SJ, Hengstler JG, Selinski S, Harland M, Teo M, Kiltie AE, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Schned A, Lenz P, Riboli E, Brennan P, Tjønneland A, Otto T, Ovsiannikov D, Volkert F, Vermeulen SH, Aben KK, Galesloot TE, Turman C, De Vivo I, Giovannucci E, Hunter DJ, Hohensee C, Hunt R, Patel AV, Huang WY, Thorleifsson G, Gago-Dominguez M, Amiano P, Golka K, Stern MC, Yan W, Liu J, Li SA, Katta S, Hutchinson A, Hicks B, Wheeler WA, Purdue MP, McGlynn KA, Kitahara CM, Haiman CA, Greene MH, Rafnar T, Chatterjee N, Chanock SJ, Wu X, Real FX, Silverman DT, Garcia-Closas M, Stefansson K, Prokunina-Olsson L, Malats N, Rothman N

UROMOL Consortium

European urology · 2023 · PMID 37210288

Questions about rs1414253

What is rs1414253?

rs1414253 is a single position in the genome, in or near the near MTAP gene. Published research associates it with bladder cancer in ever smokers. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1414253 linked to?

On MyGeneLog this position is linked to Bladder Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs1414253 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1414253 come from?

GWAS Catalog, European urology 2023, PMID:37210288. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Bladder cancer in ever smokers (rs1414253). MyGeneLog™. https://www.mygenelog.com/variants/rs1414253

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