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Uterine fibroids

ATM · rs141379009

Where this position leads

Condition: Uterine Fibroids

Drug: Metformin

rs141379009 Condition: Uterine Fibroids Uterine Fibroids Condition Drug: Metformin Metformin Drug rs141379009 rs141379009 ATM

What the study found

Who was studied 16,595 European ancestry cases, 523,330 European ancestry controls.

The effect Each copy of the G allele carried 1.29 times the odds of Uterine fibroids (95% confidence interval 1.2-1.38); p = 3 × 10−12.

How common The G allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 11, band 11q22.3 — in an intron of ATM.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Uterine fibroids compared to the general population.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Uterine fibroids.
T/T Published research associates this genotype with typical/baseline likelihood of Uterine fibroids — no copies of the reported risk allele.
Source
Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits
Rafnar T, Gunnarsson B, Stefansson OA, Sulem P, Ingason A, Frigge ML, Stefansdottir L, Sigurdsson JK, Tragante V, Steinthorsdottir V, Styrkarsdottir U, Stacey SN
and 25 more — show all
Gudmundsson J, Arnadottir GA, Oddsson A, Zink F, Halldorsson G, Sveinbjornsson G, Kristjansson RP, Davidsson OB, Salvarsdottir A, Thoroddsen A, Helgadottir EA, Kristjansdottir K, Ingthorsson O, Gudmundsson V, Geirsson RT, Arnadottir R, Gudbjartsson DF, Masson G, Asselbergs FW, Jonasson JG, Olafsson K, Thorsteinsdottir U, Halldorsson BV, Thorleifsson G, Stefansson K
Nature communications · 2018 · PMID 30194396 · open access

Questions about rs141379009

What is rs141379009?

rs141379009 is a single position in the genome, in or near the ATM gene. Published research associates it with uterine fibroids. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs141379009 linked to?

On MyGeneLog this position is linked to Uterine Fibroids. The research behind each link, and its sources, are set out on that condition page.

Does rs141379009 affect how medicines work?

ATM carries pharmacogenomic findings for Metformin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs141379009 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs141379009 come from?

GWAS Catalog, Nat Commun 2018, PMID:30194396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Uterine fibroids (rs141379009). MyGeneLog™. https://www.mygenelog.com/variants/rs141379009

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