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Who was studied at least 60,620 European ancestry cases, at least 970,216 European ancestry controls (MTAG boosted by 455,258 Alzheimer's disease samples).
The effect
Each copy of the A allele shifted the measure 0.0396 higher (95% confidence interval 0.03-0.049); p = 3 × 10−17.
Where it sits Chromosome 10, band 10q24.33 — in an intron of SH3PXD2A.
What each result means
A/ATwo copies of the version the research linked to Atrial fibrillation (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Atrial fibrillation (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Atrial fibrillation (MTAG). This is the starting point the study compared everyone against.
Nature communications · 2024 · PMID 39537608 · open access
Questions about rs141221125
What is rs141221125?
rs141221125 is a single position in the genome, in or near the SH3PXD2A gene. Published research associates it with atrial fibrillation (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs141221125 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs141221125 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs141221125 come from?
GWAS Catalog, Nature communications 2024, PMID:39537608. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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