Sensitive

Parkinson's disease or first degree relation to individual with Parkinson's disease

CNTN1 · rs141128804

Where this position leads

Condition: Parkinson's Disease

rs141128804 Condition: Parkinson's Disease Parkinson's Disease Condition rs141128804 rs141128804 CNTN1

What the study found

Who was studied 15,056 European ancestry cases, 18,618 European ancestry proxy cases, 449,056 European ancestry controls; replicated in 22,632 European ancestry cases, 968,735 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.347 higher (95% confidence interval 0.26-0.44); p = 6 × 10−14.

How common The T allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 12, band 12q12 — in an intron of MUC19.

What each result means

C/C No copy of the version the research linked to Parkinson's disease or first degree relation to individual with Parkinson's disease. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Parkinson's disease or first degree relation to individual with Parkinson's disease. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Parkinson's disease or first degree relation to individual with Parkinson's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs141128804

What is rs141128804?

rs141128804 is a single position in the genome, in or near the CNTN1 gene. Published research associates it with parkinson's disease or first degree relation to individual with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs141128804 linked to?

On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs141128804 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs141128804 come from?

GWAS Catalog, Lancet Neurol 2019, PMID:31701892. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Parkinson's disease or first degree relation to individual with Parkinson's disease (rs141128804). MyGeneLog™. https://www.mygenelog.com/variants/rs141128804

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