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ADGRB3 protein levels

near ADGRB3-DT · rs141050221

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.335 higher (95% confidence interval 0.27-0.4); p = 5 × 10−39.

How common The G allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 6, band 6q12 — between genes, 42 kb from ADGRB3-DT.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of ADGRB3 protein levels — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with ADGRB3 protein levels.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of ADGRB3 protein levels compared to the general population.
Source

Questions about rs141050221

What is rs141050221?

rs141050221 is a single position in the genome, in or near the near ADGRB3-DT gene. Published research associates it with adgrb3 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs141050221 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs141050221 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

ADGRB3 protein levels (rs141050221). MyGeneLog™. https://www.mygenelog.com/variants/rs141050221

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