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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 59,571 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0798 lower (95% confidence interval 0.052-0.108); p = 3 × 10−8.
How common The C allele had a frequency of about 96% in the people studied.
Where it sits Chromosome 6, band 6q14.1 — between genes, 170.1 kb from RNU6-261P.
What each result means
C/CTwo copies of the version the research linked to Aortic valve mean gradient. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Aortic valve mean gradient. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Aortic valve mean gradient. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 41419685 · open access
Questions about rs140798921
What is rs140798921?
rs140798921 is a single position in the genome, in or near the near RNU6-261P gene. Published research associates it with aortic valve mean gradient. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs140798921 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs140798921 come from?
GWAS Catalog, Nature genetics 2026, PMID:41419685. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Aortic valve mean gradient (rs140798921). MyGeneLog™. https://www.mygenelog.com/variants/rs140798921