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Phospholipids in very large HDL

DYNLT2B · rs140366275

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the A allele shifted the measure 0.02 mmol/L lower (95% confidence interval 0.02-0.02); p = 1 × 10⁻¹⁰.

Where it sits Chromosome 3, band 3q29 — in an intron of DYNLT2B.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Phospholipids in very large HDL compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Phospholipids in very large HDL.

G/G Published research associates this genotype with typical/baseline likelihood of Phospholipids in very large HDL — no copies of the reported risk allele.

Source

A genetic map of human metabolism across the allele frequency spectrum

Zoodsma M, Beuchel C, Yasmeen S, Kohleick L, Nepal A, Koprulu M, Kronenberg F, Mayr M, Williamson A, Pietzner M, Langenberg C

Nature genetics · 2025 · PMID 41044249 · open access

Questions about rs140366275

What is rs140366275?

rs140366275 is a single position in the genome, in or near the DYNLT2B gene. Published research associates it with phospholipids in very large hdl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs140366275 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs140366275 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs140366275 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Phospholipids in very large HDL (rs140366275). MyGeneLog™. https://www.mygenelog.com/variants/rs140366275

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