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Atopic dermatitis

GLB1 · rs140241744

Where this position leads

What the study found

Who was studied 33,262 European ancestry cases, 804,234 European ancestry controls; replicated in 7,267 East Asian ancestry cases, 219,529 East Asian ancestry controls, 2,785 African American or Afro-Caribbean cases, 3,933 African American or Afro-Caribbean controls.

The effect Each copy of the T allele shifted the measure 0.206 lower (95% confidence interval 0.14-0.27); p = 1 × 10⁻⁹.

Where it sits Chromosome 3, band 3p22.3 — in an intron of GLB1.

What ClinVar records

Classification Likely benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2019-04-20. ClinVar record 1186798 NM_000404.4(GLB1):c.955+300G>A

What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Atopic dermatitis — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Atopic dermatitis.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Atopic dermatitis compared to the general population.

Source

Genome-Wide Integration of Genetic and Genomic Studies of Atopic Dermatitis: Insights into Genetic Architecture and Pathogenesis

Chen Y, Chen W

The Journal of investigative dermatology · 2022 · PMID 35577104

Questions about rs140241744

What is rs140241744?

rs140241744 is a single position in the genome, in or near the GLB1 gene. Published research associates it with atopic dermatitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs140241744 linked to?

On MyGeneLog this position is linked to Atopic Dermatitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs140241744 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs140241744 come from?

GWAS Catalog, The Journal of investigative dermatology 2022, PMID:35577104. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Atopic dermatitis (rs140241744). MyGeneLog™. https://www.mygenelog.com/variants/rs140241744

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