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Anterior chamber depth

HTR3D · rs1401999

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 1,752 Malay ancestry individuals, 1,860 Indian ancestry individuals, 872 Chinese ancestry individuals; replicated in 824 Chinese ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.045 lower (95% confidence interval 0.030-0.060); p = 8 × 10⁻⁹.

How common The C allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 3, band 3q27.1 — in an intron of ABCC5.

What each result means

C/C Two copies of the version the research linked to Anterior chamber depth. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/G One copy of the version the research linked to Anterior chamber depth. That is a smaller link than two copies.

G/G No copy of the version the research linked to Anterior chamber depth. This is the starting point the study compared everyone against.

Source

ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma

Nongpiur ME, Khor CC, Jia H, Cornes BK, Chen LJ, Qiao C, Nair KS, Cheng CY, Xu L, George R, Tan D, Abu-Amero K

and 61 more — show all

Perera SA, Ozaki M, Mizoguchi T, Kurimoto Y, Low S, Tajudin LS, Ho CL, Tham CC, Soto I, Chew PT, Wong HT, Shantha B, Kuroda M, Osman EA, Tang G, Fan S, Meng H, Wang H, Feng B, Yong VH, Ting SM, Li Y, Wang YX, Li Z, Lavanya R, Wu RY, Zheng YF, Su DH, Loon SC, Yong VK, Allingham RR, Hauser MA, Soumittra N, Ramprasad VL, Waseem N, Yaakub A, Chia KS, Kumaramanickavel G, Wong TT, How AC, Chau TN, Simmons CP, Bei JX, Zeng YX, Bhattacharya SS, Zhang M, Tan DT, Teo YY, Al-Obeidan SA, Hon DN, Tai ES, Saw SM, Foster PJ, Vijaya L, Jonas JB, Wong TY, John SW, Pang CP, Vithana EN, Wang N, Aung T

PLoS genetics · 2014 · PMID 24603532 · open access

What people read about alongside this

Short-sightedness and screens1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1401999

What is rs1401999?

rs1401999 is a single position in the genome, in or near the HTR3D gene. Published research associates it with anterior chamber depth. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs1401999?

Subjects that appear in the title or abstract of the same papers as this rsID include short-sightedness and screens (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1401999 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1401999 come from?

GWAS Catalog, PLoS Genet 2014, PMID:24603532. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Anterior chamber depth (rs1401999). MyGeneLog™. https://www.mygenelog.com/variants/rs1401999

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