Alzheimer disease in high polygenic risk score (>65th percentile)
near S100A7A · rs140189521
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 3,180 European ancestry cases, 978 European ancestry controls.
The effect
Each copy of the A allele carried 0.04 times the odds of Alzheimer disease in high polygenic risk score (>65th percentile) (95% confidence interval 0.0139486221632158-0.133958081149667); p = 5 × 10−8.
Where it sits Chromosome 1, band 1q21.3 — between genes, 3.5 kb from S100A7A.
What each result means
A/ATwo copies of the version the research linked to Alzheimer disease in high polygenic risk score (>65th percentile). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Alzheimer disease in high polygenic risk score (>65th percentile). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Alzheimer disease in high polygenic risk score (>65th percentile). This is the starting point the study compared everyone against.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026 · PMID 42557982 · open access
Questions about rs140189521
What is rs140189521?
rs140189521 is a single position in the genome, in or near the near S100A7A gene. Published research associates it with alzheimer disease in high polygenic risk score (>65th percentile). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs140189521 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs140189521 come from?
GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2026, PMID:42557982. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Alzheimer disease in high polygenic risk score (>65th percentile) (rs140189521). MyGeneLog™. https://www.mygenelog.com/variants/rs140189521