Standard
Acute insulin response
REG3G · rs1401735
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Acute insulin response — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Acute insulin response.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Acute insulin response compared to the general population.
Source
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants
Wood AR,
Jonsson A,
Jackson AU,
Wang N,
van Leewen N,
Palmer ND,
Kobes S,
Deelen J,
Boquete-Vilarino L,
Paananen J,
Stančáková A,
Boomsma DI
and 40 more — show all
de Geus EJC,
Eekhoff EMW,
Fritsche A,
Kramer M,
Nijpels G,
Simonis-Bik A,
van Haeften TW,
Mahajan A,
Boehnke M,
Bergman RN,
Tuomilehto J,
Collins FS,
Mohlke KL,
Banasik K,
Groves CJ,
McCarthy MI,
Pearson ER,
Natali A,
Mari A,
Buchanan TA,
Taylor KD,
Xiang AH,
Xiang AH,
Gjesing AP,
Grarup N,
Eiberg H,
Pedersen O,
Chen YD,
Laakso M,
Norris JM,
Smith U,
Wagenknecht LE,
Baier L,
Bowden DW,
Hansen T,
Walker M,
Watanabe RM,
't Hart LM,
Hanson RL,
Frayling TM
Diabetes · 2017 · PMID 28490609 · open access
Questions about rs1401735
What is rs1401735?
rs1401735 is a single position in the genome, in or near the REG3G gene. Published research associates it with acute insulin response. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1401735 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1401735 come from?
GWAS Catalog, Diabetes 2017, PMID:28490609. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants