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Waist-hip ratio

CTD- 2061E9.1 · rs140087759

Where this position leads

Condition: Waist-to-Hip Ratio (Body Fat Distribution)

What the study found

Who was studied up to 1,476 Mylopotamos (founder/genetic isolate) individuals, up to 1,737 Pomak (founder/genetic isolate) individuals.

The effect Each copy of the T allele shifted the measure 1.19 higher (95% confidence interval 0.78-1.60); p = 1 × 10⁻⁸.

How common The T allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 5, band 5p14.1 — in an intron of LINC02103.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Waist-hip ratio — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Waist-hip ratio.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Waist-hip ratio compared to the general population.

Source

Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits

Southam L, Gilly A, Süveges D, Farmaki AE, Schwartzentruber J, Tachmazidou I, Matchan A, Rayner NW, Tsafantakis E, Karaleftheri M, Xue Y, Dedoussis G

and 1 more — show all

Zeggini E

Nature communications · 2017 · PMID 28548082 · open access

Questions about rs140087759

What is rs140087759?

rs140087759 is a single position in the genome, in or near the CTD- 2061E9.1 gene. Published research associates it with waist-hip ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs140087759 linked to?

On MyGeneLog this position is linked to Waist-to-Hip Ratio (Body Fat Distribution). The research behind each link, and its sources, are set out on that condition page.

Does having rs140087759 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs140087759 come from?

GWAS Catalog, Nat Commun 2017, PMID:28548082. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Waist-hip ratio (rs140087759). MyGeneLog™. https://www.mygenelog.com/variants/rs140087759

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