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Who was studied 275 Korean ancestry cases, 2,369 Korean ancestry controls; replicated in 242 Korean ancestry cases, 1,066 Korean ancestry controls.
The effect
Each copy of the C allele carried 1.98 times the odds of Crohn's disease (95% confidence interval 1.62-2.41); p = 1 × 10−11.
How common The C allele had a frequency of about 8% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — between genes, 14.5 kb from MTCO3P1.
What each result means
A/ANo copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs140068907 is a single position in the genome, in or near the HLA-DQB1 gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs140068907 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs140068907 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs140068907 come from?
GWAS Catalog, Inflamm Bowel Dis 2016, PMID:26891255. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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