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AMY2A protein levels

near COL11A1 · rs140026476

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.287 higher (95% confidence interval 0.22-0.35); p = 3 × 10⁻²⁰.

How common The A allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 1, band 1p21.1 — between genes, 51.9 kb from COL11A1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of AMY2A protein levels compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with AMY2A protein levels.

G/G Published research associates this genotype with typical/baseline likelihood of AMY2A protein levels — no copies of the reported risk allele.

Source

A scalable variational inference approach for increased mixed-model association power

Loya H, Kalantzis G, Cooper F, Palamara PF

Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs140026476

What is rs140026476?

rs140026476 is a single position in the genome, in or near the near COL11A1 gene. Published research associates it with amy2a protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs140026476 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs140026476 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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AMY2A protein levels (rs140026476). MyGeneLog™. https://www.mygenelog.com/variants/rs140026476

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