Sensitive

Alzheimer's disease (late onset)

ATP5C1 · rs139967528

Where this position leads

Condition: Alzheimer's Disease

rs139967528 Condition: Alzheimer's Disease Alzheimer's Disease Condition rs139967528 rs139967528 ATP5C1

What the study found

Who was studied up to 16,097 European ancestry cases, up to 18,077 European ancestry controls; replicated in up to 20,693 European ancestry cases, up to 30,266 European ancestry controls.

The effect Each copy of the G allele carried 6.12 times the odds of Alzheimer's disease (late onset) (95% confidence interval 3.45-10.9); p = 6 × 10−10.

Where it sits Chromosome 10, band 10p14 — a missense change in LOC105376392.

What each result means

A/A No copy of the version the research linked to Alzheimer's disease (late onset). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Alzheimer's disease (late onset). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Alzheimer's disease (late onset). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs139967528

What is rs139967528?

rs139967528 is a single position in the genome, in or near the ATP5C1 gene. Published research associates it with alzheimer's disease (late onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs139967528 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs139967528 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs139967528 come from?

GWAS Catalog, Nat Genet 2017, PMID:28714976. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer's disease (late onset) (rs139967528). MyGeneLog™. https://www.mygenelog.com/variants/rs139967528

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