Sensitive

Alzheimer disease and age of onset

near HSD17B12 · rs139675748

Where this position leads

Condition: Alzheimer's Disease

rs139675748 Condition: Alzheimer's Disease Alzheimer's Disease Condition rs139675748 rs139675748 near HSD17B12

What the study found

Who was studied 2,478 European ancestry cases, 979 ancestry controls both from the same 1,070 families.

The effect Each copy of the T allele shifted the measure 6.02 higher (95% confidence interval -); p = 2 × 10−9.

Where it sits Chromosome 11, band 11p11.2 — in an intron of MIR670HG.

What each result means

C/C No copy of the version the research linked to Alzheimer disease and age of onset. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Alzheimer disease and age of onset. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Alzheimer disease and age of onset. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs139675748

What is rs139675748?

rs139675748 is a single position in the genome, in or near the near HSD17B12 gene. Published research associates it with alzheimer disease and age of onset. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs139675748 linked to?

On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs139675748 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs139675748 come from?

GWAS Catalog, Mol Psychiatry 2016, PMID:26830138. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer disease and age of onset (rs139675748). MyGeneLog™. https://www.mygenelog.com/variants/rs139675748

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