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Testosterone levels

RUVBL2 · rs139643250

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 246,862 European and South Asian ancestry females.

The effect Each copy of the T allele shifted the measure 0.0333 higher (95% confidence interval 0.023-0.044); p = 4 × 10−10.

How common The T allele had a frequency of about 8% in the people studied.

Where it sits Chromosome 19, band 19q13.33 — in an intron of RUVBL2.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Testosterone levels — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Testosterone levels.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Testosterone levels compared to the general population.
Source
Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum
Venkatesh SS, Wittemans LBL, Palmer DS, Baya NA, Ferreira T, Hill B, Lassen FH, Parker MJ, Reibe S, Elhakeem A, Banasik K, Bruun MT
and 39 more — show all
Erikstrup C, Aagard Jensen B, Juul A, Mikkelsen C, Nielsen HS, Ostrowski SR, Pedersen OB, Rohde PD, Sørensen E, Ullum H, Westergaard D, Haraldsson A, Holm H, Jonsdottir I, Olafsson I, Steingrimsdottir T, Steinthorsdottir V, Thorleifsson G, Figueredo J, Karjalainen MK, Pasanen A, Jacobs BM, Kalantzis G, Hubers N, Lippincott M, Fraser A, Lawlor DA, Timpson NJ, Nyegaard M, Stefansson K, Magi R, Laivuori H, van Heel DA, Boomsma DI, Balasubramanian R, Seminara SB, Chan YM, Laisk T, Lindgren CM
Genes & Health Research Team · Estonian Biobank Research Team · Estonian Health Informatics Research Team · DBDS Genomic Consortium · FinnGen
Nature genetics · 2025 · PMID 40229599 · open access

Questions about rs139643250

What is rs139643250?

rs139643250 is a single position in the genome, in or near the RUVBL2 gene. Published research associates it with testosterone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs139643250 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs139643250 come from?

GWAS Catalog, Nature genetics 2025, PMID:40229599. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Testosterone levels (rs139643250). MyGeneLog™. https://www.mygenelog.com/variants/rs139643250

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