Links from this page to related variants, conditions, drugs and topics are not included for automated readers. Those connections are the Gene Knowledge Graph and are licensed as data: https://www.mygenelog.com/license
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 4,702 Admixed Latin American ancestry cases, 68,573 Admixed Latin American ancestry controls, European, African, East Asian, South Asian or Admixed American individuals (See The COVID-19 Host Genetics Initiative, v7 ALL B2).
The effect
Each copy of the A allele shifted the measure 0.191 lower (95% confidence interval 0.13-0.26); p = 1 × 10−8.
Where it sits Chromosome 1, band 1q21.3 — in an intron of KCNN3.
How common each version is
AG
KoreanKRGDB
A 100.0% · G 0.0%
KoreanKorea1K
A 100.0% · G 0.1%
World gnomAD
A 98.4% · G 1.6%
World 1000 Genomes
A 99.1% · G 0.9%
World TOPMed
A 98.5% · G 1.5%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What each result means
A/ATwo copies of the version the research linked to COVID-19 (hospitalized covid vs population). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to COVID-19 (hospitalized covid vs population). That is a smaller link than two copies.
G/GNo copy of the version the research linked to COVID-19 (hospitalized covid vs population). This is the starting point the study compared everyone against.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
COVID-19 (hospitalized covid vs population) (rs139589338). MyGeneLog™. https://www.mygenelog.com/variants/rs139589338