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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 5,065 European ancestry cases, 21,286 European ancestry controls.
The effect
Each copy of the C allele carried 1.17 times the odds of Psoriatic arthritis (95% confidence interval 1.12-1.23); p = 6 × 10−11.
How common The C allele had a frequency of about 48% in the people studied.
Where it sits Chromosome 1, band 1p36.11 — in an intron of RUNX3.
What each result means
C/CTwo copies of the version the research linked to Psoriatic arthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Psoriatic arthritis. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Psoriatic arthritis. This is the starting point the study compared everyone against.
rs1395621 is a single position in the genome, in or near the RUNX3 gene. Published research associates it with psoriatic arthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1395621 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1395621 come from?
GWAS Catalog, Arthritis & rheumatology (Hoboken, N.J.) 2022, PMID:35507331. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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