Sensitive

Endometriosis or depression (pleiotropy)

near GRIK3 · rs1395455

Where this position leads

Condition: Endometriosis and Depression: Shared Genetics

What the study found

Who was studied 17,054 endometriosis cases, 170,756 European ancestry depression cases, 191,858 controls, 329,443 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0245 higher (95% confidence interval 0.016-0.033); p = 4 × 10⁻⁸.

Where it sits Chromosome 1, band 1p34.3 — between genes, 75.9 kb from GRIK3.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Endometriosis or depression (pleiotropy) compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Endometriosis or depression (pleiotropy).

G/G Published research associates this genotype with typical/baseline likelihood of Endometriosis or depression (pleiotropy) — no copies of the reported risk allele.

Source

Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality

Adewuyi EO, Mehta D, Sapkota Y, Auta A, Yoshihara K, Nyegaard M, Griffiths LR, Montgomery GW, Chasman DI, Nyholt DR

International Endogene Consortium · 23andMe Research Team

Human genetics · 2021 · PMID 32959083

Questions about rs1395455

What is rs1395455?

rs1395455 is a single position in the genome, in or near the near GRIK3 gene. Published research associates it with endometriosis or depression (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1395455 linked to?

On MyGeneLog this position is linked to Endometriosis and Depression: Shared Genetics. The research behind each link, and its sources, are set out on that condition page.

Does having rs1395455 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1395455 come from?

GWAS Catalog, Hum Genet 2020, PMID:32959083. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Endometriosis or depression (pleiotropy) (rs1395455). MyGeneLog™. https://www.mygenelog.com/variants/rs1395455

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