SLC9A3R2 · rs139491786
Where this position leads
Condition: Blood Pressure
What the study found
Who was studied 225,112 European ancestry individuals, 63,490 African ancestry individuals, 22,802 Hispanic individuals, 4,792 Asian ancestry individuals, 2,695 Native American ancestry individuals; replicated in 445,360 individuals.
The effect Each copy of the T allele shifted the measure 1.22 mmHg lower (95% confidence interval 1.01-1.43); p = 1 × 10−29.
How common The T allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 16, band 16p13.3 — a missense change in NHERF2.
What ClinVar records
Classification
Likely benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2023-01-01.
ClinVar record 2645964 NM_001130012.3(NHERF2):c.511C>T (p.Arg171Trp)
What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs139491786 is a single position in the genome, in or near the SLC9A3R2 gene. Published research associates it with diastolic blood pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2018, PMID:30578418. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Diastolic blood pressure (rs139491786). MyGeneLog™. https://www.mygenelog.com/variants/rs139491786