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AMY1A or AMY1B or AMY1C protein levels

near AMY2B · rs139325607

Where this position leads

Condition: Celiac Disease

rs139325607 Condition: Celiac Disease Celiac Disease Condition rs139325607 rs139325607 near AMY2B

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.529 lower (95% confidence interval 0.37-0.69); p = 4 × 10−12.

How common The C allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 1, band 1p21.1 — between genes, 9.7 kb from AMY2B.

What each result means

C/C Two copies of the version the research linked to AMY1A or AMY1B or AMY1C protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to AMY1A or AMY1B or AMY1C protein levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to AMY1A or AMY1B or AMY1C protein levels. This is the starting point the study compared everyone against.
Source

Questions about rs139325607

What is rs139325607?

rs139325607 is a single position in the genome, in or near the near AMY2B gene. Published research associates it with amy1a or amy1b or amy1c protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs139325607 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs139325607 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs139325607 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

AMY1A or AMY1B or AMY1C protein levels (rs139325607). MyGeneLog™. https://www.mygenelog.com/variants/rs139325607

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