PRDM16 · rs1393064
Where this position leads
Condition: Migraine
What the study found
Who was studied 26,052 European ancestry cases, 487,214 European ancestry controls, 569 East Asian ancestry cases, 6,619 East Asian ancestry controls, 1,142 Hispanic or Latin American cases, 4,695 Hispanic or Latin American controls, 296 African American or Afro-Caribbean cases, 1,747 African American or Afro-Caribbean controls, 208 African ancestry cases, 8,357 African ancestry controls, 278 South Asian ancestry cases, 9,480 South Asian ancestry controls, 307 Other admixed ancestry cases, 7,605 Other admixed ancestry controls.
The effect Each copy of the C allele carried 1.15 times the odds of Migraine (95% confidence interval 1.13-1.17); p = 2 × 10−27.
How common The C allele had a frequency of about 22% in the people studied.
Where it sits Chromosome 1, band 1p36.32 — in an intron of PRDM16.
rs1393064 is a single position in the genome, in or near the PRDM16 gene. Published research associates it with migraine. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Migraine. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Communications biology 2021, PMID:34294844. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Migraine (rs1393064). MyGeneLog™. https://www.mygenelog.com/variants/rs1393064