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Standard

Low density lipoprotein cholesterol levels

near Y_RNA · rs139262716

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−9, with 4 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0387 lower (95% confidence interval 0.028-0.049); p = 4 × 10−10.

How common The A allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 14, band 14q12 — between genes, 2.7 kb from Y_RNA.

How common each version is

AG
Korean KRGDB
A 21.7% · G 78.3%
Korean Korea4K
A 21.7% · G 78.3%
Korean Korea1K
A 22.7% · G 77.3%
Japanese ToMMo
A 23.6% · G 76.4%
Vietnamese
A 12.5% · G 87.5%
World gnomAD
A 3.1% · G 96.9%
World 1000 Genomes
A 5.6% · G 94.4%
World TOPMed
A 3.2% · G 96.8%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A Two copies of the version the research linked to Low density lipoprotein cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Low density lipoprotein cholesterol levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Low density lipoprotein cholesterol levels. This is the starting point the study compared everyone against.
Source

Quoting this page

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Low density lipoprotein cholesterol levels (rs139262716). MyGeneLog™. https://www.mygenelog.com/variants/rs139262716

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