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Who was studied at least 757,601 European ancestry individuals (MTAG boosted by 455,258 Alzheimer's disease samples).
The effect
Each copy of the T allele shifted the measure 0.0323 higher (95% confidence interval 0.023-0.042); p = 4 × 10−11.
Where it sits Chromosome 15, band 15q24.1 — a synonymous change in MPI.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Diastolic blood pressure (MTAG) — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Diastolic blood pressure (MTAG).
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Diastolic blood pressure (MTAG) compared to the general population.
Nature communications · 2024 · PMID 39537608 · open access
Questions about rs139190144
What is rs139190144?
rs139190144 is a single position in the genome, in or near the MPI gene. Published research associates it with diastolic blood pressure (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs139190144 linked to?
On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.
Does having rs139190144 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs139190144 come from?
GWAS Catalog, Nature communications 2024, PMID:39537608. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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