Alzheimer's disease, proxy Alzheimer's disease or related dementias in APOE e4 non-carriers
near TSPEAR · rs139130053
0 312Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total3Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 2,801 African American cases, 24,684 African American controls.
The effect
Each copy of the A allele carried 0.52 times the odds of Alzheimer's disease, proxy Alzheimer's disease or related dementias in APOE e4 non-carriers (95% confidence interval 0.41-0.66); p = 4 × 10−8.
How common The A allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 21, band 21q22.3 — between genes, 16.5 kb from TSPEAR.
What each result means
A/ATwo copies of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias in APOE e4 non-carriers. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias in APOE e4 non-carriers. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Alzheimer's disease, proxy Alzheimer's disease or related dementias in APOE e4 non-carriers. This is the starting point the study compared everyone against.
Alzheimer's research & therapy · 2025 · PMID 40708016 · open access
Questions about rs139130053
What is rs139130053?
rs139130053 is a single position in the genome, in or near the near TSPEAR gene. Published research associates it with alzheimer's disease, proxy alzheimer's disease or related dementias in apoe e4 non-carriers. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs139130053 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs139130053 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs139130053 come from?
GWAS Catalog, Alzheimer's research & therapy 2025, PMID:40708016. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 312Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total3Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
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Alzheimer's disease, proxy Alzheimer's disease or related dementias in APOE e4 non-carriers (rs139130053). MyGeneLog™. https://www.mygenelog.com/variants/rs139130053