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Age-related hearing impairment

C10orf90 · rs139123090

What the study found

Who was studied 121,934 European ancestry cases, 591,699 European ancestry controls.

The effect Each copy of the A allele carried 17.32 times the odds of Age-related hearing impairment; p = 4 × 10−10.

How common The A allele had a frequency of about 47% in the people studied.

Where it sits Chromosome 10, band 10q26.2 — a missense change in C10orf90.

What each result means

A/A Two copies of the version the research linked to Age-related hearing impairment. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Age-related hearing impairment. That is a smaller link than two copies.
G/G No copy of the version the research linked to Age-related hearing impairment. This is the starting point the study compared everyone against.
Source

Questions about rs139123090

What is rs139123090?

rs139123090 is a single position in the genome, in or near the C10orf90 gene. Published research associates it with age-related hearing impairment. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs139123090 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs139123090 come from?

GWAS Catalog, Communications biology 2021, PMID:34108613. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Age-related hearing impairment (rs139123090). MyGeneLog™. https://www.mygenelog.com/variants/rs139123090

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